Request for Information

Women's Hormonal Health

The Pedersen Foundation is seeking insight from researchers and research organizations to inform its learning, strategy, and future philanthropic priorities in women's hormonal health.

Submit Your Response

Updated Submission Deadline: June 17, 2026  ·  Responses treated as confidential

Section 1 — About This RFI

Overview

Women's Hormonal Health is a broad and evolving area of research with important implications for health, well-being, and resilience across women's lifespan. In particular, hormonal transitions such as the perinatal period and menopause involve complex changes across neurological, endocrine, immune, and metabolic systems that can shape cognition, mood, and brain health in significant ways. While scientific understanding in these areas is advancing, research remains fragmented across disciplines, and important questions remain about how to translate emerging insights into practical interventions and better care.

The Pedersen Foundation is issuing this Request For Information (RFI) as a learning-oriented process to better understand the current landscape of research and emerging opportunities in women's hormonal health. Note that this is not a call for full proposals or a competitive funding round. Rather, the RFI is intended to inform the Foundation's strategy by identifying key questions, leading researchers and institutions, promising areas of inquiry, and opportunities where philanthropic investment may help accelerate progress.

As a private family foundation, The Pedersen Foundation is interested in areas where philanthropic capital can support interdisciplinary, early-stage, and integrative work that may not fit neatly within traditional funding mechanisms. Through this RFI, the Foundation seeks insight from researchers and research organizations working across women's hormonal health, with the goal of informing strategy, identifying opportunities for collaboration, and supporting real-world impact.

Purpose & Goals

What We Hope to Learn

The purpose of this RFI is to help the Foundation better understand the current landscape, gaps, perspectives, and opportunities within women's hormonal health to inform future learning, strategy, and identify potential areas where philanthropic support can help advance promising research and real-world application. The Foundation may also reach out to selected respondents to continue the conversation, explore ideas in greater depth, and identify potential opportunities for collaboration or partnership.

We aim for the RFI responses to help the Foundation with:

Research Landscape

Better understand the current landscape of research related to women's hormonal health, with particular interest in menopause, perinatal depression and related intervention opportunities with particular attention to the gut-brain axis and neurological system.

Field Gaps and Opportunities

Clarify key research questions, methodological approaches, evidence gaps, and translational opportunities across this evolving area of research.

Translation and Application

Identify how research is informing, or could better inform, clinical practice, interdisciplinary collaboration, and scalable real-world application.

Opportunities for Private Philanthropy

Highlight areas where private philanthropic support may be well positioned to accelerate progress, advance collaboration, and support meaningful impact.

Promising Areas of Research

Surface promising, underexplored, or innovative lines of research that could strengthen prevention, early detection, intervention, and brain resilience during reproductive transitions.

Areas of Interest

Topics We Welcome

Reproductive hormonal transitions involve complex and interconnected changes across multiple biological systems. These periods may represent windows of heightened neuroplasticity, during which brain circuits are both vulnerable to disruption and responsive to targeted intervention. A deeper understanding of these mechanisms may reveal opportunities to strengthen brain resilience and improve long-term cognitive and emotional wellbeing.

The Pedersen Foundation is particularly interested in research and insights that illuminate potential ways for intervention, prevention, or resilience. This may include novel conceptual frameworks, emerging biological mechanisms, or translational opportunities that could inform future clinical tools, therapeutic approaches or models of care that extend beyond hormone replacement therapy alone.

We welcome inquiries related to, but not limited to, the following topics:

Topic Areas / Domains of Interest

  • Menopause Research exploring the neurological, hormonal, cognitive, and emotional changes associated with menopause, including brain-based mechanisms underlying mood, cognition, sleep, and overall neurological health during the menopausal transition.
  • Perinatal Depression Research examining the biological, neurological, and hormonal mechanisms underlying depression and mood disorders during pregnancy and the postpartum period, including how hormonal shifts influence brain function, emotional regulation, and maternal wellbeing.
  • Gut-Brain Axis and Related Biological Systems Microbiome–hormone–brain interactions, neuroimmune mechanisms, inflammatory signaling, and gut-mediated pathways contributing to menopausal or perinatal changes in particular.
  • Autonomic, Metabolic, and Physiological Regulation Vagal tone, autonomic regulation, and nutritional or metabolic influences on brain health during reproductive transitions.
  • Hormonal Transitions Across Interconnected Systems The ways reproductive hormonal transitions interact with neurological, endocrine, immune, metabolic, and related biological systems.

Cross-Cutting Outcomes / Areas of Focus

  • Brain Resilience, Cognition and Neuroplasticity Factors that influence resilience, adaptation, or vulnerability during reproductive transitions.
  • Behavioral Health and Mental Wellness Cognitive changes, emotional regulation, mood, and broader behavioral health implications associated with hormonal transitions.
  • Longer-Term Health Implications Intersections among menopause, perinatal depression, and later-life mental health or other compounding health effects.
  • Environmental and Contextual Influences Environmental or contextual factors that may shape brain health during these transitions.

Research Lenses / Opportunity Types

  • Key Research Questions and Field Gaps Gaps in data, measurement, methodology, or conceptual framing that may be limiting progress.
  • Longitudinal and Life-Course Research Approaches that connect reproductive transitions and brain health over time.
  • Translational and Intervention-Oriented Work Research that connects biological insight to clinical, behavioral, community-based, or other applied interventions.
  • Pilots, Testing, and Implementation Work that supports early testing, implementation-focused pilots, or scalable approaches to prevention, early detection, intervention, or resilience.
  • Non-Hormonal and Complementary Approaches Circuit-based, neuromodulatory, or other systems-level approaches that may complement hormone-based therapies and support brain resilience.
  • Additional Emerging Questions Promising lines of inquiry not captured above that could advance understanding of women's hormonal health and inform future research or practice.
Eligibility

Who Should Submit

The Foundation welcomes responses from researchers, practitioners and multi-disciplinary teams whose work advances understanding of women's hormonal health. This RFI is open to:

Section 2 — RFI Submission Process

Process & Timeline

01

Prepare and Submit a Response

Review The Pedersen Foundation Women's Hormonal Health Request For Information (this website) before submitting a response, as it provides important context on the focus and intent guiding this effort. Submit your responses using the survey link provided by June 17, 2026.

02

Review

Responses will be reviewed by a committee of foundation staff and external advisors. Information will be treated as confidential and used for learning purposes only. Submissions will be reviewed to understand trends, gaps, and opportunities across the field.

03

Ongoing Learning

Insights from this RFI will help shape future funding priorities, research questions, and partnerships. A high-level deidentified report will be shared with respondents by Fall 2026 to share general trends and learnings from the RFI. The Foundation may contact a selection of submission participants to schedule additional time to gather more information, context on issues or explore potential partnership opportunities.

Ready to Submit Your Response?

All responses must be submitted using the secure online survey. The form will guide you through each section.

Begin Response Form https://forms.cloud.microsoft/r/qPJX8uXFPY
Section 3 — Frequently Asked Questions

FAQ

What is this RFI asking for?
This RFI seeks high-level ideas and insights, not full proposals. The Foundation is interested in concise descriptions of research, concepts, or areas of inquiry, including general approaches, potential impact, and approximate budgets or timelines rather than detailed project plans.
Is this RFI a funding competition?
No. This RFI is intended to inform the Foundation's learning and future strategy, not to make immediate funding decisions. Submission of an inquiry does not represent a funding commitment from the Foundation.
When is the last day to submit an RFI response?
RFI deadline is June 17, 2026.
How do I submit a response to the RFI?
Responses must be submitted using the survey link provided. Click here to view the survey or copy and paste the following link into your browser: https://forms.cloud.microsoft/r/qPJX8uXFPY
How will submissions be reviewed?
This RFI is a non-competitive learning process. Submissions will be reviewed holistically to identify themes, gaps, and opportunities across the field.
What types of disciplines or research approaches are eligible?
The Foundation welcomes perspectives from a range of disciplines, methods, and stages of work, including neuroscience, clinical research, public health, and interdisciplinary approaches. Early-stage or exploratory ideas are welcome.
Are perspectives beyond the specified "Topic Areas / Domains of Interest" welcome?
Yes, perspectives that extend beyond the current focus are highly valued, particularly those that could advance or inform women's hormonal health future research and practice.
Can I share work that is still in development?
Yes. Respondents may describe ongoing, completed, or conceptual work.
Who is encouraged to respond?
The Foundation welcomes responses from experienced researchers, interdisciplinary teams, and emerging investigators whose work advances understanding of women's hormonal health.
Can researchers outside the United States respond?
Yes. While the Foundation primarily funds work conducted in the United States, it welcomes perspectives from international researchers and collaborations that can contribute meaningful insights to the field.
Will responses remain confidential?
Responses will be reviewed internally and may be shared with The Pedersen Foundation staff and select external advisors to support the Foundation's learning process. The Foundation will not publicly attribute ideas or findings to individual respondents without permission.
How does the Foundation intend to use the findings from the RFI?
The Foundation intends to develop an aggregated high-level synthesis of themes, gaps, and opportunities identified through the RFI.
Could responding lead to future partnership opportunities?
Possibly. While this RFI is not a funding competition, insights gathered may inform future partnership opportunities, and invitations for deeper conversations may be solicited.
Who should I contact if I have questions or need assistance?
For any questions about this RFI or technical issues with submission during the response period, please contact The Pedersen Foundation at office@pedersenpf.org.
Section 4 — About The Pedersen Foundation

About Us

The Pedersen Foundation was established by George and Marilyn Pedersen following the sale of ManTech International, a strategic defense company dedicated to advancing U.S. national security. Building on their strong tradition of giving, the Foundation supports our nation's founding principles and those who serve and protect it, while investing in emerging fields of interest.

Today, our philanthropic focus includes:

Our Mission: The Pedersen Foundation is dedicated to supporting our nation's founding principles and those that serve and protect it, supporting efforts to harness the potential of neurospatial design, and furthering the health, wellbeing, and resiliency of Americans, specifically focusing on women's hormonal health and nutrition and exercise's impact on the brain. We strive to achieve measurable impact and focus on innovative, compassionate, and courageous initiatives.

Compassion Innovation Impact Patriotism Courage